The Pediatrix Center for Research, Education, Quality and Safety (CREQS) empowers health care providers to Take great care of the patient, every day and in every way.TM As part of our ongoing commitment to improving patient care through evidence-based medicine, we engage in clinical research, education, continuous quality improvement and safety initiatives. Our efforts contribute to better patient outcomes and reduced long-term health system costs, not only for our patients and hospital partners, but for all patients and providers across our specialty areas.


To help facilitate and support research efforts, Pediatrix established a Research Advisory Committee (RAC). The goal of the RAC is to design, implement and maintain a program for clinical research oversight and support that enables our practices to conduct research that is safe, effective, financially viable and legally compliant, while optimizing research opportunities. The RAC’s multidisciplinary approach involves the collaboration of both clinical and business professionals, including finance, legal and compliance experts, and has ultimately enhanced our research efforts and improved overall process flow.

With participating clinicians located throughout the country, the RAC supports a comprehensive scope of research efforts, allowing for a more in-depth look at our specialties. This nationwide perspective allows us to better anticipate future needs and opportunities.

Submit a Research Application or Ancillary FormLog into MDXPLORE™

Learn more about current research trials:

Maternal-Fetal Medicine


Impact of a Booster Course of Antenatal Steroids on Neonatal Outcome in Patients With Premature Rupture of the Membranes (ACSinPROM)
Women who are pregnant with a singleton within a certain gestation range and experiencing premature rupture of membranes are given a second course of antenatal steroids. This trial looks to discover the impact of a booster course of antenatal steroids on neonatal morbidities, including respiratory distress syndrome.



TRIDENT COVID-19: Center For Innovative Trials In Children And Adults (TRIDENT)- COVID-19
Pediatrix Medical Group and Duke Clinical Research Institute invite you to help to facilitate a study called TRIDENT COVID-19. This study is a follow-up registry study of infants who tested positive for the COVID-19 virus or whose mothers tested positive for the COVID-19 virus. The study involves completion of questionnaires when the infant is 6 and 12 months of age and review of infant and maternal medical records.

This study will help us to better understand the medical and social outcomes of mothers and children that have been exposed to and/or diagnosed with the COVID-19 virus. We do not know the long-term impact of this new infection on women or their newborn infants. Important information from this study will inform how we can improve therapies for pregnant women and their children.

TRIDENT Flyer – Spanish
Clinician Study Info Sheet COVID
FAQ Trident

Dr. Rachel Greenberg
Duke Clinical Research Institute

Dr. Reese Clark
VP Clinical Research, Pediatrix

Pediatrix Research

This study is funded by NIH/NCATS Grant 3U24TR001608-05S2

PDA Post NICU Discharge (PDA)
Varying treatment options are available for premature infants with patent ductus arteriosus (PDA). This post-discharge study follows NICU patients discharged with PDA, tracking spontaneous closure rates and incidences of pulmonary and/or cardiac events to identify risk factors associated with adverse outcomes.

Pediatric Cardiology


Long QT and Hearing Loss Registry
This observational study follows neonatal patients greater than one week of age diagnosed with unilateral or bilateral sensorineural hearing loss to determine the true incidence of long QT. The goal of the study is to determine the incidence of an abnormal ECG and the percentages of these patients with an identifiable genetic mutation as well as patients with an abnormal genetic mutation regardless of the ECG.

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Our commitment to clinical and research excellence is evidenced by our comprehensive educational and professional development opportunities offered online or during live sessions. Each year, thousands of health care providers worldwide take advantage of educational programs hosted by Pediatrix. The Pediatrix Center for Research, Education, Quality and Safety is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians. The Pediatrix Center for Research, Education, Quality and Safety is also accredited as a provider of nursing continuing professional development by the American Nurses Credentialing Center’s Commission on Accreditation.

Online Education

Available for our affiliated clinicians as well as our peers in the medical community, we continuously develop free online education activities. Online education is available in multiple formats, including video.

FREE Neonatology Grand Rounds

The Pediatrix Neonatology Grand Rounds series addresses pertinent controversial issues that influence the clinical practice of newborn medicine. Webinars are held on the first Wednesday of every month from 4-5 p.m. Eastern Standard Time.

Quality and Safety

Through the leadership of our affiliated clinicians and with the support of our CREQS, we have cultivated a culture of continuous quality improvement and safety. This is the cornerstone of our success and helps us fulfill our mission. Our team of clinical specialists leads and provides oversight for several national quality and safety programs in various subspecialties.

Learn more:

National Quality Improvement Collaboratives


National Opioid Management Collaborative (NOPC) – The Pediatrix NOPC addresses the diagnosis, treatment and management of Neonatal Abstinence Syndrome, as well as other key contributing factors such as managing opioid addiction in pregnancy and responsible prescribing practices in the perinatal period.

Specialty Quality Improvement Collaboratives



Pediatrix NICU Breakthrough Collaborative

Achieving optimal outcomes in the practice of neonatal intensive care is challenging and complex. The Pediatrix NICU Breakthrough Collaborative provides support for 100+ participating NICUs striving to improve a variety of neonatal outcomes, including mortality, late onset sepsis, NEC, bronchopulmonary dysplasia, intraventricular hemorrhage and more.


Enhanced Recovery after Cesarean Surgery (ERACS)

Enhanced recovery after surgery programs have demonstrated value by improving health outcomes and patient satisfaction while reducing costs. Our ERAC Collaborative gives our affiliated practices and hospital partners tools to assess need and implement ERAC programs.

Whole exome sequencing

Optimal management of twin pregnancy

Management of mild maternal trauma during pregnancy

Ultrasound biometry quality review

Pediatric Cardiology

Pediatrix Cardiology Quality Collaborative (MCQC)

The Pediatrix Cardiology Quality Collaborative (MCQC) leverages the power of 20 cardiology practices and over 125 Pediatric Cardiology providers across the country to compare clinical and administrative best practices for continuous quality improvement both with individual projects and through an iterative process anchored in monthly teleconferences and yearly/bi-yearly meetings. MCQC has worked closely with the American College of Cardiology’s Adult Congenital and Pediatric Cardiology Quality Network (ACC – ACPC QNet) to develop and submit quality metric process and outcomes data as part of this national collaborative backed by ACC’s National Cardiac Database Registry (NCDR).



Practicing critical decision-making, communication, task and teamwork skills with in situ scenarios promotes optimized clinical performance for high-risk, low-volume critical situations. To meet the needs of our health care providers and hospital partners, as well as our patients, Pediatrix offers a variety of customized simulation programs to instill competence and confidence with one goal in mind: improved outcomes. The highly interactive programs incorporate rapid cycle deliberate practice (RCDP) approaches to support maternal-fetal medicine, neonatology and hospital-based medicine practices including obstetrics and pediatrics.

Our Simulation Program has earned Full Accreditation status from the Society for Simulation in Healthcare (SSH) in the area of Teaching/Education from April 1, 2020 to December 31, 2025.

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HRO Safety Pathway Program


Crew Resource Management (CRM) training forms the foundation of our High Reliability Organization (HRO) Patient Safety Initiative. We have adopted CRM strategies – proven to optimize safety in aviation and aeronautics industries – to become an HRO so our health care providers can deliver the safest care while communicating efficiently and effectively. Pediatrix has implemented HRO programs across the continuum of care, including our critical care specialties and women’s and children’s service lines.

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To promote our public policy efforts at both the state and national levels, Pediatrix’s Government Relations team collaborates with physician groups, professional societies and hospital partners to safeguard access to care for clinical services.

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